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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   sRANK Ligand Polyclonal Antibody   

sRANK Ligand Polyclonal Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O35235
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35003 Da
Additional Information
Gene ID 21943
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually.
Other Names RANK Ligand, RANKLigand, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, Osteoprotegerin ligand
Target/Specificity RANKL
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (1 mg/ml) rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionssRANK Ligand Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tnfsf11
Synonyms Opgl, Rankl, Trance
Function Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (By similarity). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:24039232). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563).
Cellular Location Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 3: Cytoplasm.
Tissue Location Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T- cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung
Research Areas
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Background

RANK (receptor activator of NF-kB) is a member of the TNFR family, identified as a dendritic cell membrane protein. Murine sRANK Ligand is a soluble 19.4 kDa protein, comprising the TNF-like extracellular domain of RANKL (174 amino acids). The full length of RANK Ligand is 39.6 kDa containing 36 amino acids.

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$ 89.00
$ 245.00
Cat# ABV10997
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