|Calculated MW||35003 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually.|
|Other Names||RANK Ligand, RANKLigand, Receptor activator of nuclear factor kappa B ligand, TNF-related activation-induced cytokine, Osteoprotegerin ligand|
|Formulation||100 µg (1 mg/ml) rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||sRANK Ligand Polyclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Opgl, Rankl, Trance|
|Function||Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 3: Cytoplasm.|
|Tissue Location||Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T- cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung|
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Provided below are standard protocols that you may find useful for product applications.
RANK (receptor activator of NF-kB) is a member of the TNFR family, identified as a dendritic cell membrane protein. Murine sRANK Ligand is a soluble 19.4 kDa protein, comprising the TNF-like extracellular domain of RANKL (174 amino acids). The full length of RANK Ligand is 39.6 kDa containing 36 amino acids.
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