|Calculated MW||45010 Da|
|Application & Usage||Western blot analysis (1-2 µg/ml). However, the optimal conditions should be determined individually. The antibody detects rat PAI-1. Cross reactivity of the antibody to other species has not been determined.|
|Other Names||PAI1, PAI 1, PAI, PAI-1, Plasminogen activator inhibitor , Endothelial plasminogen activator inhibitor|
|Formulation||100 µg (0.5 mg/ml) protein A affinity purified rabbit anti-PAI-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 0.1% BSA, 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||PAI-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
PAI-1 (plasminogen activator inhibitor-1) is originally cloned from human endothelial cell and rat hepatoma cell cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI-1 inhibits both tissue-type palsminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). High PAI-1 levels are associated with an increased risk of thromboembolic disease while PAI-1 deficiency may represent an inherited autosomal recessive bleeding disorder.
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