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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IFN alpha 2b Antibody   

IFN alpha 2b Antibody

Rabbit Polyclonal Antibody

     
  • WB - IFN alpha 2b Antibody ABV11014
    Western blot analysis using Recombinant human IFN alpha 2b (100ng).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P48551
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57759 Da
Additional Information
Gene ID 3455
Application & Usage Western blotting (1-10 µg/ml). However, the optimal conditions should be determined individually.
Other Names Interferon alpha 1, Interferon alpha1, Interferon alpha
Target/Specificity IFNa 2b
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-human IFN-alpha 2b polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5mg/ml BSA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsIFN alpha 2b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFNAR2
Synonyms IFNABR, IFNARB
Function Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted
Tissue Location Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells Expressed in lymphoblastoid and fibrosarcoma cell lines
Research Areas
Citations (0)

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Background

IFN-alpha 2b is a lymphoid factor that possesses potent anti-viral activity. Human IFN-a is a 19.3 kDa protein containing 165 amino acid residues.

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$ 89.00
$ 265.00
Cat# ABV11014
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