|Calculated MW||57759 Da|
|Application & Usage||Western blotting (1-10 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||Interferon alpha 1, Interferon alpha1, Interferon alpha|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human IFN-alpha 2b polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5mg/ml BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IFN alpha 2b Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted|
|Tissue Location||Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells Expressed in lymphoblastoid and fibrosarcoma cell lines|
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Provided below are standard protocols that you may find useful for product applications.
IFN-alpha 2b is a lymphoid factor that possesses potent anti-viral activity. Human IFN-a is a 19.3 kDa protein containing 165 amino acid residues.
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