|Reactivity||Human, Mouse, Rat|
|Calculated MW||56782 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant PDI is also available separately.|
|Other Names||Protein Disulfide Isomerase|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-PDI polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||PDI (Protein Disulfide Isomerase) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ERP57, ERP60, GRP58|
|Cellular Location||Endoplasmic reticulum. Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).|
|Tissue Location||Detected in the flagellum and head region of spermatozoa (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). Human Protein Disulfide Isomerase is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro.
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