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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VEGF-B Antibody   

VEGF-B Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49765
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 21602 Da
Additional Information
Gene ID 7423
Positive Control Recombinant human VEGF-B
Application & Usage Western Blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human VEGF-B can be used as a positive control.
Other Names Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF
Target/Specificity VEGF-B
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsVEGF-B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms VRF
Function Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Cellular Location Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin
Tissue Location Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas
Research Areas
Citations (0)

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VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only thro µgh the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

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$ 245.00
$ 89.00
Cat# ABV11027
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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