|Calculated MW||93499 Da|
|Application & Usage||Western blotting (0.5-1 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes human TGF-β Receptor III. Reactivity to other species has not been tested.|
|Other Names||Transforming growth factor-beta receptor type III, Transforming growth factor-beta receptor type 3, TGF-beta type III receptor, TbetaR-III; TGFR-3, TGFG3, TGFR 3|
|Target/Specificity||TGF-b Receptor III|
|Formulation||100 µg (0.5 mg/ml) antigen affinity purified goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TGF-beta Receptor III Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.|
|Cellular Location||Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
TGF-β (Transforming growth factor-beta superfamily members are critical regulators of cell proliferation, differentiation, morphogenesis, and pathogenesis. TGF-beta receptor is a serine/threonine kinase receptor complex that consists of two distinct transmembrane proteins known as type I and type II receptors. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and thus activation of the type I receptor kinases.
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