|Calculated MW||15075 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). Per researcher’s feedback, it can also be used in neutralization (5-10 µg/ml). However, the optimal conditions should be determined individually. Recombinant human Galectin-7 can be used as a positive control.|
|Other Names||Galectin7, Galectin 7, Galectin-7, Gal-7; Gal7, GAL7, GAL-7, HKL-14; PI7; p53-induced gene 1 protein, lectin|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human Galectin-7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Galectin-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.|
|Cellular Location||Cytoplasm. Nucleus. Secreted Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Mainly expressed in stratified squamous epithelium|
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Galectin-7 belongs to growing family of evolutionary conserved animal lectins. Galectins consists of beta-galactoside binding lectins that contain homologous carbohydrate recognition domains (CRDs). Galectin has the ability to induce apoptosis of activated T-cells and T-leukaemia cell lines. Other activities include cell differentiation and inhibition activity of CD45 protein phosphatase activity. Galectin also binds beta-galactoside as well as CD45, CD3 and CD4. Recombinant Human Galectin-7 is a 15.4 kDa protein consisting of 136 amino acid residues.
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