|Calculated MW||38007 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||Follistatin, FS|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human Follisatin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Follistatin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).|
|Tissue Location||Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid|
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Provided below are standard protocols that you may find useful for product applications.
Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF-beta ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring antagonist binds to Activin, BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Human Follistatin is a 31.5 kDa protein containing 288 amino acids.
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