|Application & Usage||Western blotting (2-6 µg/ml). However, the optimal conditions should be determined individually. Recombinant human IGFBP-3 can be used as a positive control. Other applications have not been determined.|
|Formulation||200 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IGF-BP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.
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