|Calculated MW||30570 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human IGFBP-5 can be used as a positive control. Other applications have not been determined.|
|Other Names||IGFBP-5, IGFBP5, IGFBP 5, IGF-BP-5, IGF-BP 5|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human IGF-BP5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IGF-BP5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|
|Tissue Location||Osteosarcoma, and at lower levels in liver, kidney and brain|
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Provided below are standard protocols that you may find useful for product applications.
Human IGF-BP5 is a cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Studies show that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole body growth inhibition, and retarded muscle development.
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