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MMP-1 Antibody

Rabbit Polyclonal Antibody

  • WB - MMP-1 Antibody ABV11067
    Western blot analysis of MMP-1 using recombinant human MMP-1. Lane 1: 20 ng;Lane 2: 50 ng;Lane 3: 100 ng;Lane 4: 200 ng
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P03956
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 54007 Da
Additional Information
Gene ID 4312
Positive Control Recombinant human MMP-1
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
Other Names Interstitial collagenase,, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG
Target/Specificity MMP-1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsMMP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MMP1
Synonyms CLG
Function Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Cellular Location Secreted, extracellular space, extracellular matrix
Citations (0)

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are tho µght to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.  MMP1 is tho µght to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.

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$ 245.00
$ 89.00
Cat# ABV11067
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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