|Calculated MW||141720 Da|
|Positive Control||Recombinant human endostatin|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||Endostatin-XV, Related to endostatin:Restin|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human Endostatin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Endostatin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells altho µgh it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
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