|Reactivity||Human, Mouse, Rat|
|Calculated MW||74111 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). It detects the 60-80 kDa synapsins. Jurkat cell lysates and rat kidney tissue lysate can be used as positive controls. Blocking peptide is available separately.|
|Other Names||SYN, syn|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-Synapsin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Synapsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.|
|Cellular Location||Cell junction, synapse. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
Synapsins are abundant brain proteins essential for regulating neurotransmitter release. All synapsins contain a short N-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I. Phosphorylation of synapsin N-terminal domain at Ser9 inhibits its binding to phospholipids and diassociates synapsins from synaptic vesicles.
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