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EZH1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q92800 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85271 Da |
| Gene ID | 2145 |
|---|---|
| Positive Control | Western blot: Mouse spleen lysate, human spleen lysate |
| Application & Usage | Western blot: 1-2 µg/ml. However, the optimal conditions should be determined individually. |
| Other Names | Enhancer of zeste homolog 1 (Drosophila), ENX-2, ENX2, EZH1, Histone-lysine N-methyltransferase EZH1, KIAA0388 |
| Target/Specificity | EZH1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | EZH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EZH1 |
|---|---|
| Synonyms | KIAA0388 |
| Function | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
| Cellular Location | Nucleus. Note=Colocalizes with trimethylated 'Lys-27' of histone H3 |
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Provided below are standard protocols that you may find useful for product applications.
Background
EZH1 is a human homolog of the Drosophila gene Enhancer of zeste E(z), a member of the polycomb group of transcriptional repressors. In mice, EZH1 is a regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin. The strong sequence conservation between species s µggests potential role for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that stably maintain heterochromatin.
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