|Reactivity||Human, Mouse, Rat|
|Calculated MW||55595 Da|
|Positive Control||Western blot: Human brain cell lysate|
|Application & Usage||Western blot: 1-3 µg/ml. However, the optimal conditions should be determined individually.|
|Other Names||F-Box-Like/WD Repeat-Containing Protein; Transducin β-Like 1X-Related Protein 1|
|Formulation||50 µg of antibody in 100 µl PBS containing 0.2% gelatin and 0.05% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TBLR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.|
|Tissue Location||Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver|
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Provided below are standard protocols that you may find useful for product applications.
Chromatin organization plays a fundamental role in regulating transcription in eukaryotic cells. The nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid hormone receptors (SMRT) play a role in diverse transcriptional repression pathways. N-CoR and SMRT each exist in large protein complexes, and are tho µght to mediate repression, at least in part, by their ability to recruit histone deacetylases (HDAC) to generate repressive chromatin. HDAC3 is the main HDAC that associates with N-CoR and SMRT complexes and its presence is tho µght to be essential for repression. TBLR1 is a WD-40 repeat protein that also associates with N-CoR and SMRT complexes. Altho µgh TBLR1 is tho µght to be a core component of both the N-CoR and SMRT complexes, its role in these complexes remains to be elucidated.
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