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USP34 Core Antibody
Chicken Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q70CQ2 |
| Reactivity | Human |
| Host | Chicken |
| Clonality | Polyclonal |
| Isotype | Chicken IgG |
| Calculated MW | 404233 Da |
| Gene ID | 9736 |
|---|---|
| Application & Usage | Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 µg/mL |
| Other Names | FLJ43910, KIAA0570, KIAA0729, Ubiquitin Specific Protease 34 core domain. |
| Target/Specificity | USP34 Core |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 50 µg of antibody in PBS containing 10% glycerol |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | USP34 Core Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | USP34 |
|---|---|
| Synonyms | KIAA0570, KIAA0729 |
| Function | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. |
| Tissue Location | Expressed in brain at low level. |
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Provided below are standard protocols that you may find useful for product applications.
Background
USP34 Core is a ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. It acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. It recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. It is involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. Its catalytic core consists of residues 1892-2241.
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