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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NCOA1 Antibody   

NCOA1 Antibody

Rabbit Polyclonal Antibody

  • WB - NCOA1 Antibody ABV11146
    WB of testis cell extract with NCOA1 pAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15788
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 156757 Da
Additional Information
Gene ID 8648
Positive Control Western Blot: Testis cell lysates
Application & Usage Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200.
Other Names NCOA1, F­SRC­1, KAT13A, MGC129719, MGC129720, NCoA­1, RIP160, SRC­1, SRC1, bHLHe42, bHLHe74, 6/G9a
Target/Specificity NCOA1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsNCOA1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCOA1
Synonyms BHLHE74, SRC1
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981}
Tissue Location Widely expressed.
Research Areas
Citations (0)

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There are three members of the steroid receptor co­activator (SRC) family of proteins: SRC­1 (NCoA­1), SRC­2 (TIF2/GRIP1/NCoA­2), and SRC­3 (ACTR /TRAM­1/AIB1). All SRC family members share significant structural homology and function to stimulate transcription mediated by nuclear hormone receptors and other transcriptional activators such as Stat3, NF­κB, E2F1, and p53. Two SRC proteins, SRC­1 and SRC­3, function as histone acetyltransferases. In addition, all three family members can recruit other histone acetyltransferases (CBP/p300, PCAF) and histone methyltransferases (PRMT1, CARM1) to target promoters and cooperate to enhance expression of many genes. The SRC proteins play important roles in multiple physiological processes including cell proliferation, cell survival, somatic cell growth, mammary gland development, female reproductive function, and vasoprotection. SRC­1 and SRC­3 are conduits for kinase mediated growth factor signaling to the estrogen receptor and other transcriptional activators. Seven SRC­1 phosphorylation sites and six SRC­3 phosphorylation sites have been identified, which are induced by steroids, cytokines, and growth factors and involve multiple kinase signaling pathways. Research has shown that all three SRC family members are associated with increased activity of nuclear receptors in breast, prostate, and ovarian carcinomas. According to the literature, SRC­3 is frequently amplified or overexpressed in a number of cancers, and SRC­1/PAX3 and SRC­2/MYST3 translocations are found associated with rhabdomyosarcoma and acute myeloid leukemia, respectively.

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$ 335.00
Cat# ABV11146
(40 western blots)
Availability: 5-7days
Bulk Size
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