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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Peroxiredoxin IV Antibody (3A1)   

Peroxiredoxin IV Antibody (3A1)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13162
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG 1
Clone Names 3A1
Calculated MW 30540 Da
Additional Information
Gene ID 10549
Positive Control IP analysis : HeLa cell lysate. IHC staining : HeLa cells
Application & Usage Western blot: 2-4 µl/ml, IP: 1-2 µl, ICC: 20 µl/ml.
Other Names Peroxiredoxin 4, PRX-4, AOE37-2, PRDX4.
Target/Specificity Peroxiredoxin IV
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPeroxiredoxin IV Antibody (3A1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDX4
Function Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Cellular Location Cytoplasm. Secreted
Research Areas
Citations (0)

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Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 – 30 kDa in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol. Prx IV is probably involved in redox regulation of the cell. Regulates the activation of NFkappaB in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

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$ 325.00
Cat# ABV11154
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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