|Reactivity||Human, Mouse, Rat|
|Calculated MW||51456 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||Glial cell line derived neurotrophic factor, GDNF, GFR alpha, GFR a, GFR-alpha, GFR-a|
|Formulation||100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-GFRα-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||GFRalpha-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GDNFRA, RETL1, TRNR1|
|Function||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRα, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRα from human, rat, chicken and mouse have been cloned recently. GDNFRα was also termed Ret ligand 1 (RETL1) or TGF-β-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα-1 recently. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.
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