GFRalpha-1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P56159 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 51456 Da |
Gene ID | 2674 |
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Application & Usage | Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. |
Other Names | Glial cell line derived neurotrophic factor, GDNF, GFR alpha, GFR a, GFR-alpha, GFR-a |
Target/Specificity | GFRa-1 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) immunoaffinity purified rabbit anti-GFRα-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | GFRalpha-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GFRA1 |
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Synonyms | GDNFRA, RETL1, TRNR1 |
Function | Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies {ECO:0000250|UniProtKB:Q62997} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRα, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRα from human, rat, chicken and mouse have been cloned recently. GDNFRα was also termed Ret ligand 1 (RETL1) or TGF-β-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFRα-1 recently. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.
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