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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Glutathione Peroxidase 4 Antibody (Clone 1H11)   

Glutathione Peroxidase 4 Antibody (Clone 1H11)

Mouse Monoclonal Antibody

     
  • IP - Glutathione Peroxidase 4 Antibody (Clone 1H11) ABV11175
    IP analysis of HL60 cell lysates. Lane 1: Input, Lane 2: Precipitated sample
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E, IP
Primary Accession P36969
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names Clone 1H11
Calculated MW 22175 Da
Additional Information
Gene ID 2879
Positive Control WB and IP: HL60 cell lysate
Application & Usage IP: 1-2 µl, ELISA.
Other Names Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GPX4
Target/Specificity Glutathione Peroxidase 4
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGlutathione Peroxidase 4 Antibody (Clone 1H11) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPX4
Function Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion.
Cellular Location Isoform Mitochondrial: Mitochondrion.
Tissue Location Present primarily in testis.
Research Areas
Citations (0)

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Background

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic /mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

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$ 325.00
Cat# ABV11175
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