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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Ferredoxin Reductase Antibody (Clone 6C2)   

Ferredoxin Reductase Antibody (Clone 6C2)

Mouse Monoclonal Antibody

     
  • WB - Ferredoxin Reductase Antibody (Clone 6C2) ABV11178
    WB analysis. Lane 1: HeLa cell lysate, Lane 2: Jurkat,cell lysate, Lane 3: 293 T cell lysate
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P22570
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names Clone 6C2
Calculated MW 53837 Da
Additional Information
Gene ID 2232
Positive Control WB: Jurkat, HeLa and 293 T cell lysate
Application & Usage WB
Other Names NADPH: adrenodoxin oxidoreductase, mitochondrial, FDXR, ADXR
Target/Specificity Ferredoxin Reductase
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFerredoxin Reductase Antibody (Clone 6C2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FDXR
Synonyms ADXR
Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Cellular Location Mitochondrion matrix.
Research Areas
Citations (0)

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Background

Ferredoxin reductase is a ubiquitous flavoenzyme, containing noncovalently bound FAD as a prosthetic group. It plays a role in delivering NADPH or low potential one-electron donors such as ferredoxin and flavodoxin to redox-based metabolisms in plastids, mitochondria and bacteria. In mammals, ferredoxin reductase is loosely associated with the inner mitochondrial membrane and receives electrons from NADPH. These electrons are transferred to ferredoxin which shuttles electrons to cytochrome P450 in the adrenal cortex mitochondrial steroid hydroxylation systems. It serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

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$ 325.00
Cat# ABV11178
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