|Reactivity||Human, Mouse, Rat|
|Calculated MW||23659 Da|
|Application & Usage||Western Blot - 1: 1000 dilution|
|Other Names||Fibronectin Type III Domain-containing Protein 5 (cleaved); Fibronectin Type III Repeat-containing Protein 2 (cleaved); FNDC5 (cleaved)|
|Formulation||1 mg/ml in PBS containing 10% glycerol and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Irisin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Peroxisome membrane; Single-pass type I membrane protein. Note=Imported in peroxisomes through the PEX5 receptor pathway.|
|Tissue Location||Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen|
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Provided below are standard protocols that you may find useful for product applications.
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
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