|Clone Names||Clone: Stiny-3|
|Calculated MW||93314 Da|
|Application & Usage||ELISA|
|Other Names||Osteoblast-specific Factor 2; OSF-2; Postn|
|Formulation||1 mg/ml in PBS containing 10% glycerol and 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Periostin Antibody (Clone: Stiny-3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.|
|Cellular Location||Golgi apparatus. Secreted, extracellular space, extracellular matrix. Note=Colocalizes with BMP1 in the Golgi.|
|Tissue Location||Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor Overexpressed in breast cancers.|
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Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor β1 (TGF-β1) and bone morphogenetic protein 2 (BMP-2). Abnormal expression of Periostin is also linked to angiogenesis and metastasis in epithelial tumors.
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