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UCP1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - UCP1 Antibody ABV11193-50
    Immunohistochemistry of UCP1 in human liver tissue with UCP1 antibody at 2.5 μg/ml.
  • WB - UCP1 Antibody ABV11193-50
    Western blot analysis of UCP1 in HeLa cell lysate with UCP1 antibody at 1 μg/mL.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession P25874
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 33005 Da
Additional Information
Gene ID 7350
Positive Control Western blot: HeLa cell lysate. Immunohistochemistry: Human liver tissue.
Application & Usage Western blot: 1 - 2 µg/mL, IHC: 2.5 µg/mL, ELISA
Other Names Uncoupling protein 1, mitochondrial brown fat uncoupling protein 1, solute carrier family 25 member 7, SLC25A7, Thermogenin
Target/Specificity UCP1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 1 mg/ml in PBS containing 0.02% sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsUCP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UCP1 (HGNC:12517)
Function Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane (PubMed:24196960). However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633}
Tissue Location Brown adipose tissue.
Research Areas
Citations (0)

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Background

The mitochondrial brown fat uncoupling protein 1 (UCP1) is a member of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP1 is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

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$ 335.00
Cat# ABV11193-50
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