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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Superoxide Dismutase 1 (SOD-1) Antibody   

Superoxide Dismutase 1 (SOD-1) Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00441
Other Accession AAR21563
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 15936 Da
Additional Information
Gene ID 6647
Positive Control Western Blot: 3T3 cell lysate, rat kidney lysate
Application & Usage Western blot: 1:200
Other Names Superoxide Dismutase 1, SODC
Target/Specificity SOD1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg or 30 µg (0.5 mg/ml) of antibody in PBS containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsSuperoxide Dismutase 1 (SOD-1) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOD1
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria
Research Areas
Citations (0)

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Superoxide Dismutase (SOD) is an oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. It belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occurring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.

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$ 245.00
$ 89.00
Cat# ABV11197
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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