|Reactivity||Human, Mouse, Rat|
|Calculated MW||186456 Da|
|Positive Control||Western blot: Jurkat Cell lysate|
|Application & Usage||Western blot: 1-4 µg/ml.|
|Other Names||A-kinase anchor protein SPHKAP, SPHK1 interactor, AKAP domain containing, DKFZp781H143, DKFZp781J171, KIAA1678, MGC132614 antibody, MGC132616, SKIP antibody, A-kinase anchor protein Sphingosine kinase type 1-interacting protein, SPHK1 (Sphingosine kinase type 1) interacting protein, SPHK1-interactor and AKAP domain-containing protein, SPHK1 interactor, AKAP domain.|
|Formulation||100 µg or 30 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||SPHKAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.|
|Cellular Location||Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm|
|Tissue Location||Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
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