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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   PARP Antibody (Clone 839120)   

PARP Antibody (Clone 839120)

Mouse Monoclonal Antibody

  • WB - PARP Antibody (Clone 839120) ABV11210
    Western blot with HeLa cell lysate and PARP antibody (1 4g/ml). A specific band was detected at ~ 110 kDa.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P09874
Other Accession NP_001609
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Calculated MW 113084 Da
Additional Information
Gene ID 142
Positive Control Western Blot: HeLa cell lysate, IHC: human breast tissue.
Application & Usage WB: 1 µg/ml, IHC: 8-25 µg/ml.
Other Names PARP1, ADPRT, PPOL, NAD (+) ADP-ribosyltransferase 1
Target/Specificity PARP
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of 0.5 mg/ml antibody in sterile PBS.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPARP Antibody (Clone 839120) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PARP1
Synonyms ADPRT, PPOL
Function Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Cellular Location Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage
Research Areas
Citations (0)

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PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

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$ 325.00
Cat# ABV11210
(40 western blots)
Availability: 5-7days
Bulk Size
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