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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GHBP Antibody   

GHBP Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10912
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 71500 Da
Additional Information
Gene ID 2690
Positive Control Western Blot: Recombinant protein
Application & Usage Western blot: 1-4 µg/ml.
Other Names GHR, GHBP, GH receptor, Growth hormone binding protein, Somatotropin receptor
Target/Specificity GHBP
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg or 30 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGHBP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GHR
Function Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. Growth hormone-binding protein: Secreted. Note=Complexed to a substantial fraction of circulating GH
Tissue Location Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver
Research Areas
Citations (0)

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GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 30.3 kDa.

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$ 275.00
$ 89.00
Cat# ABV11211
(40 western blots)
Availability: 5-7days
Bulk Size
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