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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Granzyme A Antibody   

Granzyme A Antibody

Rabbit Polyclonal Antibody

  • WB - Granzyme A Antibody ABV11234
    Western blot with Granzyme A antibody. Lane 1: 50 μg Mouse muscle lysate; Lane 4: 50 μg Rat kidney lysate2; Lane 3: 2 ng Human recombinant Granzyme A; Lane 4: 10 ng Human recombinant Granzyme A
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12544
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28999 Da
Additional Information
Gene ID 3001
Positive Control Western Blot: mouse muscle lysate, rat kidney lysate, recombinant protein
Application & Usage Western blot: 1-4 µg
Other Names CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF
Target/Specificity Granzyme A
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGranzyme A Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CTLA3, HFSP
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Cellular Location Isoform alpha: Secreted. Cytoplasmic granule
Research Areas
Citations (0)

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Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells. Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme A is the most abundant serine protease in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Granzyme A has a specific function in CTL and NK cells. It induces caspase-independent cell death when introduced into target cells by perforin. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates

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$ 245.00
$ 89.00
Cat# ABV11234
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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