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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Caspase 1 Antibody   

Caspase 1 Antibody

Rabbit Polyclonal Antibody

  • WB - Caspase 1 Antibody ABV11238
    Western blot with caspase-1 Antibody. Lane 1: 60 μg Jurkat cell lysate; Lane 2: 33 μg Mouse muscle lysate; Lane 3: 1 ng Mouse Recombinant Caspase 1; Lane 4: 5 ng Mouse Recombinant Caspase 1; Lane 5: 25 ng Mouse Recombinant Caspase 1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29452
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 45640 Da
Additional Information
Gene ID 12362
Positive Control Western Blot: Jurkat cell lysate, mouse muscle lysate, recombinant protein
Application & Usage Western blot: 1-4 µg
Other Names CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme
Target/Specificity Caspase 1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Casp1
Synonyms Il1bc
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Cellular Location Cytoplasm.
Tissue Location High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle
Research Areas
Citations (0)

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Caspase-1 (also known as ICE) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme. The pro-enzyme is matured by proteolysis to yield large (20 kDa) and small (10 kDa) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the regulatory mechanism of caspase-1 activation and the role of caspase-1 in apoptosis are poorly understood. In THP-1 cells, a large proportion of the caspase-1 is present in the inactive proenzyme form.

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$ 265.00
$ 89.00
Cat# ABV11238
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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