|Reactivity||Human, Mouse, Rat|
|Calculated MW||25039 Da|
|Positive Control||Western Blot: Jurkat cell lysate, mouse muscle lysate, rat kidney lysate, recombinant protein|
|Application & Usage||Western blot: 1-4 µg|
|Other Names||C-Reactive Protein|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CRP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.|
|Tissue Location||Found in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
C-Reactive protein (CRP) is an acute-phase protein that can have both pro-and anti-inflammatory effects. CRP is synthesized by the liver in response to factors released by fat cells or adipocytes. CRP is a member of the pentaxin family of proteins and in its native form is composed of five identical subunits, non-covalently linked to form a symmetrical disc of ~ 115 KDa. Widely used as a clinical marker of the state of inflammation. Increased CRP levels are found in inflammatory conditions including: bacterial infection, rheumatic fever, active arthritis, myocardial infarction, malignancies and in the post-operative state.
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