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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   FTO Antibody (Clone FT86-4)   

FTO Antibody (Clone FT86-4)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C0B1
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1k
Clone Names FT86-4
Calculated MW 58282 Da
Additional Information
Gene ID 79068
Application & Usage ELISA, IP, Western Blot
Other Names FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein.
Target/Specificity FTO
Antibody Form Liquid
Appearance Colorless liquid
Formulation 0.2 µm-filtered solution in PBS, pH 7.4
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFTO Antibody (Clone FT86-4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FTO
Synonyms KIAA1752
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Cellular Location Nucleus. Nucleus speckle
Tissue Location Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
Research Areas
Citations (0)

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FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

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$ 245.00
Cat# ABV11249
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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