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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AGT Antibody (CT)   

AGT Antibody (CT)

Rabbit Polyclonal Antibody

  • WB - AGT Antibody (CT) ABV11258
    Western blot analysis of anti-AGT Antibody (C-term) in HepG2 cell line lysates (35 μg/lane). AGT (arrow) was detected using the purified pAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01019
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 53154 Da
Additional Information
Gene ID 183
Positive Control Western blot: HepG2 cell lysate, IHC: human hepatocarcinoma tissue
Application & Usage Western blot: ~1:1000, IHC: ~1:10-1:50
Other Names AGT; SERPINA8; Angiotensinogen; Serpin A8; Angiotensin-1; Angiotensin I; Angiotensin-2; Angiotensin II; Angiotensin-3; Angiotensin III;
Target/Specificity AGT
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAGT Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGT
Synonyms SERPINA8
Function Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. Angiotensin-3: stimulates aldosterone release.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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Angiotensinogen, also known as AGT and SERPINA8, is a member of the serpin family. It is anα-2-globulinthat is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. It is expressed by the liver and secreted in plasma. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD).

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$ 245.00
Cat# ABV11258
(40 western blots)
Availability: 5-7days
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