|Application ||WB, IHC|
|Calculated MW||41213 Da|
|Positive Control||Western blot: HL60 cell lysate, IHC: human hepatocarcinoma tissue|
|Application & Usage||Western blot: ~1:1000, IHC: ~1:10-1:50.|
|Other Names||APOA5; RAP3; Apolipoprotein A-V; Apolipoprotein A5; Regeneration-associated protein 3|
|Formulation||100 µl of antibody in PBS with 0.09% (W/V) sodium azide|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ApoA5 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.|
|Tissue Location||Liver and plasma.|
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Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5.
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