|Application ||WB, IHC|
|Calculated MW||11284 Da|
|Positive Control||Western blot: HL60 and A549 cell line lysates , IHC: human liver tissue|
|Application & Usage||Western blot: ~1:1000, IHC: ~1:10-1:50.|
|Other Names||APOC2; APC2; Apolipoprotein C-II; Apolipoprotein C2|
|Formulation||100 µl of antibody in PBS with 0.09% (W/V) sodium azide|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ApoC2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.|
|Tissue Location||Liver and intestine.|
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Provided below are standard protocols that you may find useful for product applications.
Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene.
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