|Application ||WB, IHC|
|Calculated MW||35399 Da|
|Positive Control||Western blot: CEM cell line, IHC: human hepatocarcinoma tissue|
|Application & Usage||Western blot: ~1:1000, IHC: ~1:10-1:50.|
|Other Names||APOF; Apolipoprotein F; Lipid transfer inhibitor protein|
|Formulation||100 µl of antibody in PBS with 0.09% (W/V) sodium azide|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||ApoF Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Apolipoproteins are a family of fatty-acid binding proteins that transport fat through the bloodstream in the form of lipoproteins. ApoF (apolipoprotein F), also known as LTIP (lipid transfer inhibitor protein), is a 308 amino acid secreted protein that belongs to the apolipoprotein family. Expressed in liver tissues and also existing in plasma, ApoF inhibits the activity of CETP (cholesteryl ester transfer protein) and, via this inhibition, functions to regulate cholesterol transport. The gene encoding ApoF maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
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