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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BDNF Antibody (CT)   

BDNF Antibody (CT)

Rabbit Polyclonal Antibody

  • FC - BDNF Antibody (CT) ABV11275
    Flow cytometric analysis of CEM cells using BDNF Antibody (CT) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IF - BDNF Antibody (CT) ABV11275
    Confocal immunofluorescent analysis of BDNF Antibody (CT) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • IHC - BDNF Antibody (CT) ABV11275
    Formalin-fixed and paraffin-embedded human brain tissue reacted with BDNF antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - BDNF Antibody (CT) ABV11275
    Western blot analysis with CEM cell line lysates (35 μg/lane). BDNF (arrow) was detected using the purified pAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23560
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27818 Da
Additional Information
Gene ID 627
Positive Control Western blot: CEM cell line, IHC: human brain tissue, FACS: CEM cells, IF: NCI-H460 cells
Application & Usage Western blot: ~1:1000, IHC: ~1:10–1:50, IF: ~1:10–1:50, FC: ~1:10–1:50.
Other Names BDNF; Brain-derived neurotrophic factor; Abrineurin
Target/Specificity BDNF
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBDNF Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Cellular Location Secreted.
Tissue Location Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta
Research Areas
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Neurotrophins function to regulate naturally occurring cell death of neurons during development. The prototype neurotrophin is nerve growth factor (NGF), originally discovered in the 1950s as a soluble peptide promoting the survival of, and neurite outgrowth from, sympathetic ganglia. Three additional structurally homologous neurotrophic factors have been identified. These include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) (also designated NT-5). These various neurotrophins stimulate the in vitro survival of distinct, but partially overlapping, populations of neurons. The cell surface receptors through which neurotrophins mediate their activity have been identified. For instance, the Trk A receptor is the preferential receptor for NGF, but also binds NT-3 and NT-4. The Trk B receptor binds both BDNF and NT-4 equally well, and binds NT-3 to a lesser extent, while the Trk C receptor only binds NT-3.

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$ 245.00
Cat# ABV11275
(40 western blots)
Availability: 5-7days
Bulk Size
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