|Application ||WB, IHC|
|Calculated MW||104844 Da|
|Positive Control||Western blot: HL60 cell lysate, IHC: human brain tissue|
|Application & Usage||Western blot: ~1:1000, IHC: ~1:10–1:50.|
|Other Names||BICC1; Protein bicaudal C homolog 1|
|Formulation||100 µl of antibody in PBS with 0.09% (W/V) sodium azide|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BICC1 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.|
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BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein that belongs to the BICC family. BICC1 is considered a putative RNA-binding protein and may be involved in regulating gene expression during embryonic development by modulating protein translation. Existing as two alternatively spliced isoforms, BICC1 contains two KH domains as well as one SAM (sterile α motif) domain. Both BICC1 isoforms are widely expressed in normal tissues and are found in all brain regions including cerebral cortex, hippocampus and midbrain, although BICC1 isoform 1 is more highly expressed than isoform 2, particularly in nerve tissue. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain dependent manner, suggesting that the different BICC1 isoforms may play varying biological roles. Genetic variants in BICC1 may be involved in recurrent unipolar major depression. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
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