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LDHA Antibody (Center)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC |
|---|---|
| Primary Accession | P00338 |
| Reactivity | Human, Rat, Monkey, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36689 Da |
| Gene ID | 3939 |
|---|---|
| Positive Control | Western blot: Ramos and A375 cell line lysates, IHC: skin tissue, FACS: HeLa cells |
| Application & Usage | Western blot: ~1:1000, IHC: ~1:50–1:100, FACS: ~1:10-1:50. |
| Other Names | LDHA; L-lactate dehydrogenase A chain; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; Renal carcinoma antigen NY-REN-59. |
| Target/Specificity | LDHA |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µl of antibody in PBS with 0.09% (W/V) sodium azide |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | LDHA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LDHA (HGNC:6535) |
|---|---|
| Function | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
L-Lactate dehydrogenase A chain (LDHA) is a member of the LDH/MDH superfamily and LDH family. It catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential. Mutations in LDHA have been associated with in LDHA are the cause of glycogen storage disease type 11 (GSD11) which is a metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.
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