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ANGPTL1 Antibody (NT)

Rabbit Polyclonal Antibody

     
  • FC - ANGPTL1 Antibody (NT) ABV11311-100
    ANGPTL1 Antibody flow cytometric analysis of Hela cells(right histogram)compared to a negative control cell(left histogram). Fitch-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, FC
Primary Accession O95841
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Positive Control Western blot: HeLa cell lysate, IHC: Human placenta tissue, FACS: HeLa cells.
Application & Usage Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10–1:50.
Other Names ANGPTL1; ANG3; ANGPT3; ARP1; Angiopoietin-related protein 1; Angiopoietin-3; Angiopoietin-like protein 1
Target/Specificity ANGPTL1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsANGPTL1 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANGPTL1
Synonyms ANG3, ANGPT3, ARP1
Cellular Location Secreted.
Tissue Location Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach EMBL; AF107253; AAD19608.1; -; mRNA EMBL; AY358278; AAQ88645.1; -; mRNA EMBL; AB056476; BAB40691.1; -; mRNA EMBL; AL355520; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC050640; AAH50640.1; -; mRNA CCDS; CCDS1327.1; - RefSeq; NP_004664.1; NM_004673.3 RefSeq; XP_005245634.1; XM_005245577.2 UniGene; Hs.591474; - ProteinModelPortal; O95841; - SMR; O95841; - STRING; 9606.ENSP00000234816; - iPTMnet; O95841; - PhosphoSitePlus; O95841; - BioMuta; ANGPTL1; - EPD; O95841; - PaxDb; O95841; - PeptideAtlas; O95841; - PRIDE; O95841; - ProteomicsDB; 51085; - Ensembl; ENST00000234816; ENSP00000234816; ENSG00000116194 Ensembl; ENST00000367629; ENSP00000356601; ENSG00000116194 GeneID; 9068; - KEGG; hsa:9068; - UCSC; uc001gma.4; human CTD; 9068; - DisGeNET; 9068; - EuPathDB; HostDB:ENSG00000116194.12; - GeneCards; ANGPTL1; - HGNC; HGNC:489; ANGPTL1 HPA; HPA009976; - MIM; 603874; gene neXtProt; NX_O95841; - OpenTargets; ENSG00000116194; - PharmGKB; PA24794; - eggNOG; KOG2579; Eukaryota eggNOG; ENOG410ZYS4; LUCA GeneTree; ENSGT00920000148944; - HOGENOM; HOG000037129; - HOVERGEN; HBG103336; - InParanoid; O95841; - OMA; QLWCENS; - OrthoDB; EOG091G03M1; - PhylomeDB; O95841; - TreeFam; TF336658; - SignaLink; O95841; - SIGNOR; O95841; - GeneWiki; ANGPTL1; - GenomeRNAi; 9068; - PRO; PR:O95841; - Proteomes; UP000005640; Chromosome 1 Bgee; ENSG00000116194; - CleanEx; HS_ANGPTL1; - ExpressionAtlas; O95841; baseline and differential Genevisible; O95841; HS GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB GO; GO:0005615; C:extracellular space; IDA:MGI GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl CDD; cd00087; FReD; 1 InterPro; IPR036056; Fibrinogen-like_C InterPro; IPR002181; Fibrinogen_a/b/g_C_dom InterPro; IPR020837; Fibrinogen_CS Pfam; PF00147; Fibrinogen_C; 1 SMART; SM00186; FBG; 1 SUPFAM; SSF56496; SSF56496; 1 PROSITE; PS00514; FIBRINOGEN_C_1; 1 PROSITE; PS51406; FIBRINOGEN_C_2; 1 2: Evidence at transcript level; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal SIGNAL 1 23 CHAIN 24 491 Angiopoietin-related protein 1 /FTId=PRO_0000009118 DOMAIN 271 491 Fibrinogen C-terminal {ECO:0000255|PROSITE-ProRule:PRU00739} COILED 80 168 CARBOHYD 160 160 N-linked (GlcNAc...) asparagine CARBOHYD 188 188 N-linked (GlcNAc...) asparagine DISULFID 280 309 {ECO:0000255|PROSITE-ProRule:PRU00739} DISULFID 432 445 {ECO:0000255|PROSITE-ProRule:PRU00739} SEQUENCE 491 AA; 56720 MW; 3C4DB8DEF6CF7E99 CRC64; MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA YTFLVPEQRI TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ RDPGYPRDLM PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW LGLENIYMLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL RAVQMMIKPI D
Research Areas
Citations (0)

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Background

Angptl1 (angiopoietin-like 1), also known as angioarrestin, ARP1, ANGPT3 or previously known as angiopoietin 3 (ANG3), is a member of the angiopoietin-like family. It is highly expressed in adult tissues, particularly adrenal gland, thyroid, placenta and small intestine. Angptl1 exists as a disulfide-linked dimer and shares 45.1% identity with Ang-1 and 59% identity with Angptl2. Angptl1 consists of an N-terminus with a coiled-coil domain, potential glycosylation sites and a C-terminus with a fibrinogen-like domain. It is a secreted protein but does not function as a growth factor in endothelial cells. Angptl1 plays a distinct role in the regulation of angiogenesis; inhibiting proliferation, migration, tube formation and endothelial cell adhesion. To exert this inhibitory activity, Angptl1 is speculated to interact with a receptor on endothelial cells. In a wide variety of tumor tissues, Angptl1 expression is down-regulated suggesting that a major function of this protein involves its antiangiogenic properties.

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$ 245.00
Cat# ABV11311-100
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