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FTO Antibody (NT)

Rabbit Polyclonal Antibody

  • IHC - FTO Antibody (NT) ABV11314
    Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
  • WB - FTO Antibody (NT) ABV11314
    Western blot analysis of NCI-H460 cell line lysate. (35 Hg protein).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C0B1
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 58282 Da
Additional Information
Gene ID 79068
Positive Control Western blot: NCI-H460 cell lysate, IHC: human brain tissue , FACS: NCI-H292 cells.
Application & Usage Western blot: ~1:1000, IHC: ~1:50-1:100, FACS: ~1:10–1:50.
Other Names FTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein.
Target/Specificity FTO
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFTO Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FTO
Synonyms KIAA1752
Function Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Has no activity towards 1- methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Cellular Location Nucleus. Nucleus speckle
Tissue Location Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
Research Areas
Citations (0)

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FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

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$ 245.00
Cat# ABV11314
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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