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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   OCT4 (OCT3) Antibody   

OCT4 (OCT3) Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01860
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38571 Da
Additional Information
Gene ID 5460
Positive Control Western blot: HL-60 cell lysate, IF: Sy5Y cells
Application & Usage Western blot: ~1:1000, IF: ~1:10–1:50.
Other Names POU5F1; OCT3; OCT4; OTF3; POU domain, class 5, transcription factor 1; Octamer-binding protein 3; Octamer-binding protein 4; Octamer-binding transcription factor 3
Target/Specificity Oct4/Oct3
Antibody Form Liquid
Appearance Colorless liquid
Formulation Supplied in PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsOCT4 (OCT3) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POU5F1
Synonyms OCT3, OCT4, OTF3
Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Cellular Location Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
Tissue Location Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
Research Areas
Citations (0)

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Oct-4 (POU5F1) is a transcription factor highly expressed in undifferentiated embryonic stem cells and embryonic germ cells. A network of key factors that includes Oct-4, Nanog, and Sox2 is necessary for the maintenance of pluripotent potential, and downregulation of Oct-4 has been shown to trigger cell differentiation. Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker. Oct-4 exists as two splice variants, Oct-4A and Oct-4B. Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency, while Oct-4B may exist in some somatic, non-pluripotent cells.

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$ 265.00
Cat# ABV11315
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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