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Runx2 Antibody

Rabbit Polyclonal Antibody

  • IHC - Runx2 Antibody ABV11319
    RUNX2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
  • WB - Runx2 Antibody ABV11319
    RUNX2 Antibody western blot analysis in CEM cell line lysates (35 μg/lane).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Additional Information
Positive Control Western blot: CEM cell lysate, IHC: human tonsil tissue, FACS: NCI-H460 cells.
Application & Usage Western blot: ~1:1000, IHC: 1:10 – 1:50, FACS: 1:10 – 1:50.
Other Names RUNX2; AML3; CBFA1; OSF2; PEBP2A; Runt-related transcription factor 2; Acute myeloid leukemia 3 protein; Core-binding factor subunit alpha-1; Oncogene AML-3; Osteoblast-specific transcription factor 2; Polyomavirus enhancer-binding protein 2 alpha A subunit; SL3-3 enhancer factor 1 alpha A subunit; SL3/AKV core-binding factor alpha A subunit
Target/Specificity Runx2
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsRunx2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Citations (0)

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The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2åB, CBFA2), RUNX2 (also designated AML-3, PEBP2åA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPåC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.

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$ 245.00
Cat# ABV11319
(40 western blots)
Availability: 5-7days
Bulk Size
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