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Thy1/CD90 Antibody (NT)

Rabbit Polyclonal Antibody

     
  • IHC - Thy1/CD90 Antibody (NT) ABV11321-100
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with THY1 antibody (NT) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
    detail
  • WB - Thy1/CD90 Antibody (NT) ABV11321-100
    Western blot analysis of anti-THY1 (NT) Pab pre-incubated without (lane 1) and with (lane 2) blocking peptide (BP2050a) in T47D cell line lysate. THY1 (NT) (arrow) was detected using the purified Pab.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P04216
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 17935 Da
Additional Information
Gene ID 7070
Positive Control Western blot: T47D, HL60 cell lysate, IHC: human hepatocarcinoma and cancer tissue .
Application & Usage WB: 1:1000, IHC: 1:50 – 1:100.
Other Names Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, CD90, THY1
Target/Specificity Thy1/CD90
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsThy1/CD90 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THY1
Function May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Cellular Location Cell membrane; Lipid-anchor, GPI- anchor
Citations (0)
citation

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Background

Thy1 is a GPI-anchored, developmentally regulated protein involved in various signaling cascades that mediate neurite outgrowth, T cell activation, tumor suppression, apoptosis, and fibrosis. It is highly expressed on the surface of adult neurons and is thought to play a role in modulating adhesive and migratory events, such as neurite extension. Decreased Thy1 expression is associated with the development of epithelial ovarian cancer, revealing its role as a putative tumor suppressor gene of human ovarian cancer. Thy1 knockout mice have impaired cutaneous immune responses and abnormal retinal development. Thy1 is epigenetically regulated or deregulated in some disease states, such as pulmonary fibrosis. The potentially reversible hypermethylation of the Thy1 promoter offers the possibility of novel therapeutic options in this disease.

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Discontinued
Cat# ABV11321-100
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