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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BMPR2 Antibody (NT)   

BMPR2 Antibody (NT)

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13873
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 115201 Da
Additional Information
Gene ID 659
Positive Control Western blot: mouse heart tissue lysate, IHC: human hepatocarcinoma and kidney tissues, FACS: HepG2 cells.
Application & Usage WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.
Other Names BMPR2; PPH1; Bone morphogenetic protein receptor type-2; Bone morphogenetic protein receptor type II
Target/Specificity BMPR2
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBMPR2 Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMPR2
Synonyms PPH1
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in heart and liver.
Research Areas
Citations (0)

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BMPR2 is a type II serine/threonine receptor kinase that binds to an array of secreted bone morphogenetic proteins (BMPs). BMPs belong to the superfamily of TGF-β ligands that modulate gastrulation, neurogenesis, chondrogenesis, interdigital cell death, and bone morphogenesis. In contrast to the TGF-β type II receptor, BMPR2 contains an extended carboxyl-terminal region that interacts with multiple signaling molecules to modulate the responsiveness of target genes to BMPs. BMP signaling requires oligomerization of both type I and type II receptors to elicit a functional response of target genes. BMP binding to type I and II receptors induces Smad1/5/8 phosphorylation which is required for the activation of target genes. In vitro and in vivo evidence suggests that defects in BMPR2 may contribute to pulmonary hypertension, inflammation, and endothelial injury.

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$ 265.00
Cat# ABV11322
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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