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NGFR Antibody (Clone # 8G3G10)

Mouse Monoclonal Antibody

  • IHC - NGFR Antibody (Clone # 8G3G10) ABV11327
    NGFR Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
  • WB - NGFR Antibody (Clone # 8G3G10) ABV11327
    Western blot analysis of NGFR Antibody in mouse heart tissue lysates (35 μg/lane). NGFR (arrow) was detected using the purified MAb (1:1000).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08138
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names Clone # 8G3G10
Calculated MW 45183 Da
Additional Information
Gene ID 4804
Positive Control Western blot: mouse heart tissue lysate, IF: SY5Y cells, FACS: human brain tissue.
Application & Usage WB: 1:500 – 1:2000, IHC: 1:50 – 1:100, IF: 1:100.
Other Names CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR
Target/Specificity NGFR
Antibody Form Liquid
Appearance Colorless liquid
Formulation This antibody is purified through a protein G column, followed by dialysis against PBS.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsNGFR Antibody (Clone # 8G3G10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TNFRSF16
Function Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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NGFR, a 75 kd glycoprotein (also known as P-75NTR), is the first of neurotrophin receptors to be isolated and is a member of the tumor necrosis factor (TNF) receptor family. It is expressed not only in sympathetic and sensory neurons, but also in various neural crest cell or tumor derivatives such as melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurofibromas, and neurotized nevi (type C melanocytes). NGFR has been shown to be a reliable marker for desmoplastic and neurotropic melanoma by several groups. It is now apparent that expression of NGFR is ubiquitous and not limited to the nervous system, being expressed in mature nonneural cells such as perivascular cells, follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells and myoepithelial cells. Studies in prostate and urothelial cancer suggest that NGFR may act as a tumour suppressor, negatively regulating cell growth and proliferation. Anti-NGFR labels the myoepithelial cells of breast ducts and intralobular fibroblasts of breast ducts and thus aides in the diagnosis of malignancy in the breast.

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$ 245.00
Cat# ABV11327
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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