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HLA-A Antibody (Clone # 7G7F9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Other Accession | N/A |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1, 2bk |
| Clone Names | Clone # 7G7F9 |
| Positive Control | Western blot: Ramos cell lysate. |
|---|---|
| Application & Usage | WB: 1:500 – 1:1000. |
| Other Names | HLA-A; HLAA; HLA class I histocompatibility antigen, A-3 alpha chain; MHC class I antigen A*3 |
| Target/Specificity | HLA-A |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | Crude ascites with 0.09% (W/V) sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | HLA-A Antibody (Clone # 7G7F9) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind peptides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A encodes a membrane anchored heavy chain which hetero-dimerizes with a light chain (b-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-A alleles.
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