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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ANPEP/CD13 Antibody (Clone # 505CT12.1.2)   

ANPEP/CD13 Antibody (Clone # 505CT12.1.2)

Mouse Monoclonal Antibody

  • WB - ANPEP/CD13 Antibody (Clone # 505CT12.1.2) ABV11332
    ANPEP/CD13 Antibody western blot analysis in HepG2 cell line lysates (35 μg/lane).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15144
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG2a
Clone Names 505CT12.1.2
Calculated MW 109540 Da
Additional Information
Gene ID 290
Positive Control Western blot: HepG2 cell lysate.
Application & Usage WB: 1:100 – 1:250
Other Names ANPEP; APN; CD13; PEPN; Aminopeptidase N; Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase
Target/Specificity ANPEP/CD13
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsANPEP/CD13 Antibody (Clone # 505CT12.1.2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms APN, CD13, PEPN
Function Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Cellular Location Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detected
Tissue Location Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients
Research Areas
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CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.

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$ 245.00
Cat# ABV11332
(40 western blots)
Availability: 5-7days
Bulk Size
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