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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   ANPEP/CD13 Antibody (Clone # 505CT12.1.2)   

ANPEP/CD13 Antibody (Clone # 505CT12.1.2)

Mouse Monoclonal Antibody

     
  • WB - ANPEP/CD13 Antibody (Clone # 505CT12.1.2) ABV11332-100
    ANPEP/CD13 Antibody western blot analysis in HepG2 cell line lysates (35 μg/lane).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P15144
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG2a
Clone Names 505CT12.1.2
Calculated MW 109540 Da
Additional Information
Gene ID 290
Positive Control Western blot: HepG2 cell lysate.
Application & Usage WB: 1:100 – 1:250
Other Names ANPEP; APN; CD13; PEPN; Aminopeptidase N; Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase
Target/Specificity ANPEP/CD13
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsANPEP/CD13 Antibody (Clone # 505CT12.1.2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANPEP
Synonyms APN, CD13, PEPN
Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization.
Cellular Location Cell membrane; Single-pass type II membrane protein. Note=Also found as a soluble form
Tissue Location Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients
Research Areas
Citations (0)

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Background

CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.

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$ 245.00
Cat# ABV11332-100
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