|Application ||WB, IHC, FC|
|Calculated MW||70578 Da|
|Positive Control||Western blot: Mouse heart tissue lysate, IHC: mouse heart tissue, FACS: NCI-H292.|
|Application & Usage||WB: 1:1000, IHC: 1:10 – 1:50, FC: 1:10 – 1:50.|
|Other Names||ENG; END; Endoglin|
|Formulation||In PBS with 0.09% (W/V) sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||CD105/Endoglin Antibody (Center E395) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endoglin is restricted to endothelial cells in all tissues except bone marrow|
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Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways. Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos. Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure. The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer.
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