|Application ||WB, E|
|Calculated MW||88061 Da|
|Positive Control||Western blot: NIH3T3 cells, ELISA: peptides.|
|Application & Usage||Western Blot: 1:1000, ELISA: 1:100.|
|Other Names||FSRG1, NAT, RING3, RNF|
|Formulation||In PBS with 0.05% (W/V) sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BRD2 polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.|
|Cellular Location||Nucleus. Note=Detected on chromatin and nucleosomes|
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Brd2, a mitogen-activated kinase localized to the nucleus, is a putative transcriptional regulator which interacts with E2F1 and with histone H4 acetylated at ‘Lys-13’. It is expressed during development and may be involved in growth control. Brd2 also may play a role in spermatogenesis or folliculogenesis and may be involved in some types of leukemia and in juvenile myoclonic epilepsy.
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